Acute Inflammatory Marker In Canine And Feline

What are cCRP/fSAA?

Both cCRP and fSAA are the APPs (Acute Phase Protein). They are the highly sensitive marker of acute inflammation but no specificity. When systemic inflammation occurs, APPs reaction is more rapid than leukocytes. APPs decrease with treatment, so APPs are positively correlated with disease duration. In clinical, APPs are very suitable for diagnosing, monitoring the inflammation and prognostic assessment.

cCRP/fSAA is more suitable as an inflammatory marker than leukocytes (WBC)

● cCRP/fSAA are respectively the major APPs in dogs and cats. ● Levels of cCRP/fSAA in healthy dogs and cats are extremely low. ● When inflamed, cCRP/fSAA response is faster than WBC and they     are positively correlated with disease duration.

● It is not easily affected by antiinflammatory drugs. ● CRP/fSAA are serve as the prognostic assessment of inflammation.

When to Use cCRP/fSAA?

1. Routine test at first diagnosis 2. Systemic inflammation assessed 3. Monitoring after inflammation treated 4. Prognostic assessment of inflammation 5. Recovery after surgery

Indications

Diseases that cCRP may Increase	Diseases that fSAA may Increase
Pyometra	Dermatitis
Sterile nodular panniculitis	Rhinitis
Acute Pancreatitis	Myocarditis
Rheumatoid arthritis	Hepatitis
Multiple arthritis	Gastroenteritis
Autoimmune hemolytic anemia	Cholangitis
Acute lymphoblastic leukemia	Feline Infectious Peritonitis
Malignant Histiocytosis	Nephritis
Bronchopneumonia/ Pneumonia	Cystitis
Chronic hepatitis	Diabetes
Intestinal obstruction	Renal Failure
Surgical trauma	Trauma
Terminal cancer	Terminal cancer
Microbial infection	Microbial infection

Note. The change of cCRP/fSAA is slightly difference between different breeds and different individuals.

Test Result

AmiShield Canine CRP	AmiShield Feline SAA

Normal : Healthy without inflammation.
Abnormal : There may be mild or severe inflammatuon in vivo. It needs to be combined with symptoms and other detailed tests to clarify the disease.
                    Please cooperate with the diagnosis and treatment of the veterinarian.

♦ Reference
1. Evidence of an acute phase response in dogs naturally infected with Babesia canis. Vet Parasitol. 2007 Mar 31;144(3-4):242-50.
2. Serum acute phase protein concentrations in female dogs with mammary tumors. J Vet Diagn Invest. 2009 Mar;21(2):214-9. 
3. C-reactive protein concentration in dogs with various diseases. J Vet Med Sci. 2008 Feb;70(2):127-31. 
4. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol. 2005 Jun;34(2):85-99